Alkali metal salts of 3.3&lt;1&gt;-diamino-4.4&lt;1&gt;dioxyarsenobenzene combined with copper and process of making same.



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PAUL' EHRLICH AND IPAUL KARRER, OF FRANKFORT-ON-THE-MAIN, GERMANY, AS-SIGNORS T FARBWERKE VORM. MEISTER LUCIUS & BRUNING, OF HOCHST-ON-THE-MAIN, GERMANY, A CORPORATION OF- GERMANY.

- To all whom it may ALKALI METAL SALTS OF3.3-DIAMINO-4.41-DIOXYAIRSEN0BENZENE COMBINED \VITH COPPER AND PROCESSOF MAKING SAME.

No Drawing.

concern: Be it known that we, PAUL Ennnron,

M. 1)., professor-of medicine, and PAUL Ph. D., chemist, citizens of theEmand Republic of Switzerland, respectively, residing atFrankfort-onthe-Main, Germany, have invented certain new and usefulImprovements in Alkali Metal Salts of 3.3-Diambic-4.4:-Dioxyarsenobenzene Combined with Copper and Process ofMaking Same, of which the following is a specification. 1

\Ve have found that new compounds of the3.3-diamino-+l.4-dioxyarsenobenzene can be obtained by treating with analkali the compounds produced by th ombination ofdiaminodioxyarsenobenzene vith acopper salt.

The procedure 'for preparing the new compound may, for instance, be asfollows: The compound obtained from diaminodioxyarsenobenzenehydroehlorid and copper chlorid may be dissolved by means of causticalkali and the new product precipitated from this solution by means ofalcohol. The new product constitutes an alkali salt of thedioxydiaminoarscnobenzene combined with copper and forms a dark powder;it dissolves in water with alkaline reaction and is insoluble in alcoholand ether, it changes in the air and thereby becomes insoluble in water.The product is of great thcrapeutical value in the treatment ofinfectious diseases, particularly sleeping-sickness.

The following vcntion.

Example l: 40 grams of the compound from diamincdioxyarsenobenzenehydrochlorid and cupric chlorid. the preparation of which is describedin U. S. Patent No. 1,091,881, dated March solved with 240 c. c. of 2 N.caustic soda-lye and the solution thus obtained is run, while stirring,into r liters of alcohol. The newcompound separates and is filtered,washed with alcohol and ether and dried in oac'uo. In order to preventany decomposition, the said operations should be carried out in aKARnEn, pire of Germany examples illustrate our in- Specificatlon oiLetters Patent. Application filed January 24, 1914. Serial No. 814,216.

31, 1914, are dis- Patented Nov. 17, 19M.

nitrogen ,5()

atmosphere. The new compound may, at

course, also be prepared without isolating the combination ofdianiinodioxyarsenolumzenc and euprie chl'orid, namely by adding analkali to its solution obtained by combining the components, theprocedure being as follows 2 Example II: 5 grams of 3.3-diamino-4.4-dioxyarscnobenze-ne are dissolved in =10 c. c. of water, a solution of1.8 grams of crystal lizcd cupric chlorid dissolved in '15 c. c. ofwater is added and then are introduced, while well stirring and coolingwith ice, 8 c. e. of 10 N. caustic sod-.ulyc. After the whole iscompletely dissolved. it is liltercd in 900 c. c. of alcohol. Thefurther opera tion may be carried out as indicated in Example I.

l-laving now described our invention, what we claim is:

- 1. As new products, the 3.3 dianiino 4-.4 (lit)XyitlSQl'lUhtlIlZtbllOcombined with copper bound in a complex form, being dark powdersdissolving in watcr with alkaline reaction, insoluble in alcohol andether, and which change in the air 75 and thereby become insoluble inwater.

Q. As a new product. the sodium salt of the 3.3 diamino 4.1lioxyarsenobenzene combined with copper bound in a complex form, being adark powder, dissolving in water with alkaline reaction. insoluble inalcohol and other and which changes in the air and thereby becomesinsoluble in water.

3. The process, which consists in treating with alkali the compoundsobtainable by combining 3.25 diamino: 4.1 dioxyarsenobenzene withcopper-salts.

4. The process, which consists in treating i with alkali the compoundobtainable by combining 3.3 diamino 1.4 dioxyarsenobenzene with copperchlorid.

In testimony whereof", we aflix our signatures in presence of twowitnesses.

PAUL I Jl'RLICH. PAUL KARRER.

alkali metal salts of

